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4171 - 4180 of 71486 results found

Adaptive designs in critical care trials: a simulation study

Date
Wednesday, October 18, 2023 - 4:00 AM
Description
CONCLUSIONS: This study confirms the right adaptive design can reach the same conclusion as a fixed design with a much-reduced sample size. The efficiency gain associated with an increased number of interims is highly relevant to late-phase critical

Adaptive evolution of the Spike protein in coronaviruses

Date
Thursday, April 13, 2023 - 4:00 AM
Description
Coronaviruses are single-stranded, positive-sense RNA viruses that can infect many mammal and avian species. The Spike (S) protein of coronaviruses binds to a receptor on the host cell surface to promote viral entry. The interactions between the S

Adaptive immune cells are necessary for SARS-CoV-2-induced pathology

Date
Wednesday, January 03, 2024 - 4:00 AM
Description
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the ongoing global pandemic associated with morbidity and mortality in humans. Although disease severity correlates with immune dysregulation, the cellular mechanisms of

Adaptive interventions for alcohol misuse and violent behaviors among adolescents and emerging adults in the emergency department: A sequential multiple assignment randomized controlled trial protocol

Date
Saturday, May 06, 2023 - 4:00 AM
Description
Alcohol use and violent behaviors among youth are associated with morbidity and mortality. An emergency department (ED) visit provides an opportunity to initiate prevention efforts. Despite promising findings from our single session SafERteens brief